Pathogenesis of bovine adenoviral infections in newborn calves Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/t148fk46s

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  • Three newborn, colostrum deprived calves were inoculated by the intranasal, intratracheal, conjunctival and oral routes with a subgroup II bovine adenovirus strain 7T. An initial viremia and febrile response occurred in all calves with widespread dissemination of the virus through the body. Clinical signs consisted of pyrexia, soft feces and diarrhea. Virus isolation from serum samples indicated pyrexia was associated with a viremia of short duration. Virus was isolated from the feces beginning one day following the onset of viremia. At necropsy, virus was recovered from many organs sampled including those of the lower respiratory tract, gastrointestinal tract, genital tract, and central nervous sytem. The virus was rarely isolated from the upper respiratory tract. Parenteral, serum-virus neutralizing antibody was not present in two calves necropsied seven days post inoculation but was present in low concentration in one calf 10 days post inoculation. Fluorescent antibody staining of tissues indicated virus replication throughout the respiratory and enteric tracts as well as other tissues of all calves. Major characteristics of pathogenesis, parameters for further study, and criteria for viral isolation and disease detection and diagnosis were discussed.
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