The effect of exhaustive endurance exercise and vitamin B-6 supplementation on vitamin B-6 metabolism and growth hormone in men Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/t722hc999

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • Trained male cyclists (6 in study 1, 5 in study 2) cycled to exhaustion (EXH) at 75% of VO₂ max twice; once in the non-supplemented (NS) state and once in the vitamin B-6 (B-6)(20 mg PN) supplemented (S) state. The diet contained 2.3 mg B-6 in study 1 and 1.9 mg B-6 in study 2. Urine was collected during each dietary period. During each exercise (EX) test, blood was drawn prior to (PRE), one hour during (DX), immediately after (POST) and one hour after (POST 60) EX and sweat was collected. Compared to baseline (PRE) levels, plasma pyridoxal 5'-phosphate (PLP) and vitamin B-6 (PB-6) concentrations increased at DX, decreased at POST, and decreased below PRE at POST 60 in the NS and S states. EX to EXH in the S state resulted in a greater increase in PLP DX in study 1 (31% increase vs. 16%) and PB-6 in study 2 (25% increase vs. 11%) as compared to the NS state. Red blood cell (RBC) PLP significantly increased from POST to POST 60 in the S state in study 2. The excretion of urinary 4-pyridoxic acid (4-PA) and urinary B-6 (UB-6) was not significantly altered by EX to EXH. The mean excretion of 4-PA was significantly greater in the NS state in study 2 (7.98 ±1.83 mmol/d) as compared to the excretion in study 1 (6.20 ±0.93 mmol/d), whereas the excretion was significantly greater in the S state in study 1 (92.2 ±8.69 mmol/d) compared to the excretion in study 2 (82.7 ±6.16 mmol/d). The percent of B-6 intake excreted as UB-6 (6% in study 1 and 10% in study 2) was significantly different between the studies in the NS state. Vitamin B-6 supplementation did not significantly alter the rise in growth hormone (hGH) concentration seen with EX to EXH. The loss of B-6 in sweat with EX to EXH was not altered by B-6 supplementation. The loss of B-6 in sweat ranged from 0.0011 mmol to 0.0039 mmol. Therefore, EX to EXH in the B-6 S state resulted in a greater increase in plasma PLP and PB-6 DX as compared to the NS state. The decrease in PB-6 and PLP at POST 60 in the S state coincided with a significant increase in RBC PLP, suggesting the movement of B-6 from the plasma into the RBC at POST 60. EX to EXH and B-6 supplementation did not alter the excretion of 4-PA or UB-6 suggesting that B-6 metabolism was unchanged. The loss of B-6 in sweat was comparable to previously reported values and was not altered by B-6 supplementation. B-6 supplementation did not alter the changes in hGH resulting from EX to EXH alone.
Resource Type
Date Available
Date Copyright
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi (Monochrome) using Scamax Scan+ V.1.0.32.10766 on a Scanmax 412CD by InoTec in PDF format. LuraDocument PDF Compressor V.5.8.71.50 used for pdf compression and textual OCR.
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2012-01-26T20:28:02Z (GMT) No. of bitstreams: 1 DUNTONNANCY1994.pdf: 4642422 bytes, checksum: fde3bd87e843c449995655c109f666cf (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2011-12-19T18:19:18Z (GMT) No. of bitstreams: 1 DUNTONNANCY1994.pdf: 4642422 bytes, checksum: fde3bd87e843c449995655c109f666cf (MD5)
  • description.provenance : Made available in DSpace on 2012-01-26T20:28:02Z (GMT). No. of bitstreams: 1 DUNTONNANCY1994.pdf: 4642422 bytes, checksum: fde3bd87e843c449995655c109f666cf (MD5) Previous issue date: 1994-11-04
  • description.provenance : Submitted by Erin Clark (ecscannerosu@gmail.com) on 2011-12-16T20:39:31Z No. of bitstreams: 1 DUNTONNANCY1994.pdf: 4642422 bytes, checksum: fde3bd87e843c449995655c109f666cf (MD5)

Relationships

In Administrative Set:
Last modified: 08/15/2017

Downloadable Content

Download PDF
Citations:

EndNote | Zotero | Mendeley

Items