Graduate Thesis Or Dissertation
 

Method development for characterizing the hydrophobicity of engineered nanoparticles

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/t722hd25q

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  • Characterizing the hydrophobicity of nanoparticles can help us understand their fate and transport in the environment, as well as how nanoparticles may interact with biological systems. However, contact angle and partition coefficient have limitations in measuring the hydrophobicity of nanoparticles, thus promising methods to measuring the hydrophobicity of nanoparticles are needed. Hydrophobic interaction chromatography (HIC) and dye adsorption were used to test the hydrophobicity of nanoparticles in this study. HIC used hydrophobic interaction between hydrophobic ligand and nanoparticles to determine hydrophobicity of nanoparticles. The hydrophobicity of carboxylated nanocrystalline cellulose (CNC) is pH dependent and was used to assess the sensitivity of HIC assay. Relative hydrophobicity of metal oxides can be related to their isoelectric point (IEP) was supported by HIC. Besides, the surface coatings dominated the hydrophobicity of nanoparticles was also discussed. Dye adsorption studies were conducted using gold nanorods. By amount of hydrophobic dye adsorbed on to nanoparticles can determine their hydrophobicity. Comparing these two methods, dye adsorption can show the continuum from the hydrophobic to hydrophilic and quantified the hydrophobicity, thus it is a more promising way to measure the nanoparticle hydrophobicity than HIC.
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