Graduate Thesis Or Dissertation
 

Ration and toxicant preexposure influence dieldrin accumulation by rainbow trout

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  • Whole body accumulation and tissue distribution of dieldrin (HEOD1) in rainbow trout was studied through oral dose disposition tests and subchronic exposures via water (0.04 and 0.08 jig dieldrin/l) and/or diet (0.087 jig dieldrin/g fish/day). Growth and maintenance rations of 4 and 2% body weight/day were employed. Subchronic testing produced apparent steady state residue concentrations dependent on ration and exposure concentration after eight weeks exposure. At 16 weeks, mean whole fish residue concentrations ranged from 120 to 1400 ng dieldrin/g fish. Exposure through food and water under conditions of growth produced the highest values (1300-1400 ng dieldrin/g fish). Maintenance rations apparently limited accumulation to a maximum of 360 ng dieldrin/g fish. Whole body dieldrin concentration calculated on the basis of total lipids greatly reduced the differences in residue levels due to ration. Disposition tests were conducted on fish administered dieldrin via the diet for 2, 4 and 6 weeks and naive fish (no pretreatment). The 1 HEOD: endo exo isomer of 1,2,3,4,10,10-hexachloro-6,7-expoxy-1,4,4a, 5,6,7,8,8a-octahydro-1,4,5,8-dimethanonaphthalene disposition of a single oral dose of radiolabelled dieldrin was determined 48 hours following administration. Retention of the dose was relatively constant at 0, 2, and 6 weeks with a downward trend for most tissues and a 2 and 5 fold increase in retention of label in the bile of fish receiving maintenance and growth treatments, respectively. After 4 weeks pretreatment, label concentrations in all tissues except the bile, gut, and gut contents increased 3 to 30 fold compared to label retained by naive fish.
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