Gas-phase fragmentation chemistry of protonated peptide ions Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/v405sc58g

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • The fragmentation characteristics of protonated peptides have been investigated using tandem mass spectrometry (MS/MS) under various fragmentation regimes and detailed density functional theory (DFT) reaction pathway calculations. The DFT calculations predict novel salt-bridge stabilized transition structures as well as consecutive reactions occurring in proton-bound dimers for some of the ions detected in the MS/MS experiments. Four previously unknown protonated peptide fragmentation mechanisms are described in this thesis based on the theoretical and experimental results. These results have been evaluated using the mobile proton model and the more recently introduced pathways in competition (PIC) protonated peptide fragmentation model. The mobile proton model cannot adequately explain these experimental findings. The PIC model on the other hand, considers post-cleavage as well as pre-cleavage and bond-cleavage events, which enable these complicated protonated peptide fragmentation pathways to be rationalized.
Resource Type
Date Available
Date Copyright
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Committee Member
Academic Affiliation
Non-Academic Affiliation
Keyword
Subject
Rights Statement
Language
File Format
File Extent
  • 2016780 bytes
Replaces
Additional Information
  • description.provenance : Made available in DSpace on 2007-12-10T18:25:52Z (GMT). No. of bitstreams: 1 BJBythellPhD.pdf: 2016780 bytes, checksum: 9d835b0ca19a5c7236f9188fea3c8b35 (MD5)
  • description.provenance : Approved for entry into archive by Laura Wilson(laura.wilson@oregonstate.edu) on 2007-12-10T18:25:52Z (GMT) No. of bitstreams: 1 BJBythellPhD.pdf: 2016780 bytes, checksum: 9d835b0ca19a5c7236f9188fea3c8b35 (MD5)
  • description.provenance : Submitted by Benjamin Bythell (bythellb@onid.orst.edu) on 2007-12-07T22:46:43Z No. of bitstreams: 1 BJBythellPhD.pdf: 2016780 bytes, checksum: 9d835b0ca19a5c7236f9188fea3c8b35 (MD5)
  • description.provenance : Approved for entry into archive by Julie Kurtz(julie.kurtz@oregonstate.edu) on 2007-12-10T16:56:30Z (GMT) No. of bitstreams: 1 BJBythellPhD.pdf: 2016780 bytes, checksum: 9d835b0ca19a5c7236f9188fea3c8b35 (MD5)

Relationships

In Administrative Set:
Last modified: 08/01/2017

Downloadable Content

Download PDF
Citations:

EndNote | Zotero | Mendeley

Items