Graduate Thesis Or Dissertation
 

Effect of dimethyl sulfoxide on nutrient digestibility

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/v692t837x

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  • Workers with dimethyl sulfoxide (DMSO) in the United States and England have reported in the literature that the chemical affects the weight gaining ability of experimental animals. Narula, University of Oregon Medical School, Portland, found that 50 parts per million DMSO increased the size and numbers of tissue culture cells. Furthermore, Arscott, at Oregon State University, found that poultry whose diet contained 25 parts per million DMSO gained weight faster than others whose diet did not. Accordingly, these concentrations were used in experiments to determine if DMSO would increase digestibility and digestive enzyme activity. Fifty parts per million DMSO were added to diets made somewhat indigestible to rats by addition of fiber or of blood protein. This screening test determined if the added DMSO would increase overall body, liver, and kidney size. Statistically there was no significant difference in organ size, but the percentage of body weight, represented by liver and kidney weights, did suggest that DMSO had promoted growth of the rats on the blood protein diet. A pilot digestibility trial with four rats suggested that total dry matter protein digestibility had been improved by the addition of 50 parts per million DMSO. Further investigation was considered to be warranted. Digestibility trials were conducted with rats on high fiber, high fat, and indigestible protein diets with and without DMSO. Total dry matter digestibility in all cases was not significantly affected, and in individual cases fat, fiber, and protein digestibilities were unaffected significantly. The offspring produced by the DMSO-fed rats were normal and healthy after breeding at the conclusion of the trials. The enzymes rennen, lipase, cellulase, and alpha amylase were used in experiments to determine if concentrations of 25 and 50 parts per million DMSO added to their substrates would increase their activities. Rennen, lipase, and cellulase were unaffected, and although there were some apparent trends toward improved alpha amylase activity, statistical treatment of data from this trial showed no significant effect of the chemical on enzyme activity. In summary, DMSO did not increase diet digestibility by rats fed 50 parts per million of the chemical, and enzyme activity was unaffected by addition of the DMSO.
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