A study of some physiological properties of ovine and bovine utero-ovarian arteries Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/v692t9110

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  • The utero-ovarian vasculature of domestic animals has been a popular research subject, especially concerning the roles of the uteroovarian artery and vein in the unilateral luteolytic phenomenon demonstrated in these animals. No reports in the literature, however, have been found regarding the smooth muscle physiology of these vessels. The present study was undertaken to investigate some of the basic physiological properties of the utero-ovarian arteries from sheep and beef. Perfusion chambers equipped with platinum electrodes were utilized to examine the response characteristics of these vessels to exogenously administered pharmacologic agents and to periarterial sympathetic nerve stimulation. Also, a preliminary fluorescence histochemical study was made of a pair of bovine utero-ovarian arteries. In sheep, an association between the presence of a corpus luteum and the physiological responses of utero-ovarian arteries was demonstrated. Arteries serving the ovaries bearing corpora lutea responded to norepinephrine, epinephrine, and serotonin with significantly greater changes in perfusion pressure than did the arteries associated with ovaries not having a luteal body. Vasoconstrictor responsiveness to periarterial sympathetic nerve stimulation agreed with these findings, In addition, baseline perfusion pressures were elevated for the arteries from the corpus luteum side of the animal. The hormonal state of the sheep at the time of sacrifice also appeared to influence the vascular smooth muscle. Utero-ovarian arteries removed during the luteal phase (Day 13) of the estrous cycle elicited greater responses to vasoactive biogenic amines than the arteries removed at the time of ovulation (Day 0), but due to small sample size and extreme intra-animal variability, it was not possible to show these differences to be significantly different. Using utero-ovarian arteries of bovine origin, a similar relationship between the presence of a corpus luteum and the physiological properties of the smooth muscle was demonstrated. The arteries serving corpus luteum-containing ovaries responded with significantly greater vasoconstrictor responses to each of the biogenic amines administered at various doses. The data for sympathetic nerve stimulation suggested similar findings with the arterial segments from the corpus luteum side eliciting greater changes in perfusion pressure. As in sheep, the mean initial baseline tone of the arteries from the corpus luteum-bearing ovary was significantly greater than that of its counterpart. In addition, vascular responsiveness of bovine uteroovarian arteries was investigated during the continuous infusion of prostaglandin Fla, the propounded luteolysin in domestic animals. While prostaglandin Fla itself did not alter perfusion pressures, responses to both periarterial sympathetic nerve stimulation and administration of norepinephrine were significantly increased. The preliminary histochemical study of a pair of bovine uteroovarian arteries was undertaken to ascertain if there was a visually demonstrable difference between corpus luteum-associated arteries and arteries adjacent to ovaries lacking a luteal body. Biogenic aminecontaining nerve fibers were not visualized in either the vascular wall or its surrounding connective tissue. What was seen, however, is that the adventitia of the vessels is heavily populated with highly fluorescent mast cells which appear to completely ring the vessel and to contain histamine; there were no observable differences between the two arteries. The findings of this single study cannot be interpreted as unequivocal evidence that adrenergic innervation to these arteries is absent. Further examination of this vascular tissue using this microscopic procedure, as well as other techniques, is recommended.
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  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2013-11-20T19:54:29Z (GMT) No. of bitstreams: 1 KuhlLyndaM1975.pdf: 726686 bytes, checksum: 2b3f3087bb524ce0eb6d953981dc0588 (MD5)
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