This thesis presents accurate and time-optimal smooth reference trajectory generation techniques for manufacturing equipment such as high-speed machine tools (MT) and industrial robots (IR). Typical machining tool-paths for MTs and IRs are defined as a series of discrete linear moves. Although Point-to-Point (P2P) feed motion can be generated by interpolating each linear segment with high-order velocity proﬁles, the continuous and accurate transition between consecutive segments is necessary to realize a non-stop contouring motion for efficient manufacturing. To generate continuous feed motion along sharp cornered tool-paths, most numerical control (NC) systems blend (smooth) corners locally using various curves and splines. The feed (speed) is reduced around the blend sections so that the motion system’s kinematic limits are respected. This thesis proposes 2 novel techniques to enable modern MT and IR to generate non-stop rapid motion along discrete tool-paths. Firstly, a Kinematic Corner Smoothing (KCS) technique has been proposed to generate time-optimal (minimum time) motion trajectories in a real-time within axis kinematic limits. A novel real-time interpolation technique based on Finite Impulse Response (FIR) filtering has also been proposed to suppress residual vibrations for high positioning accuracy of machine tools and motion systems as well. These two techniques are tailored for Cartesian structured motion systems such as 2-3 axis machine tools. Finally, a decoupled FIR filtering technique has been developed to synchronously interpolate tool position and orientation for accurate motion generation for 5-axis MTs and IRs. These techniques are computationally lightweight and suitable for real-time implementation on modern NC systems. Simulation and experimental validation on Cartesian and 5-axis machine tools are presented to validate the effectiveness of the developed algorithms to interpolate along with discrete commands for high-speed and high-accuracy motion.