Size criterion for intercalation of hydrocarbon in DNA Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/vh53x060x

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  • Intercalation of hydrocarbon in DNA
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  • The binding of fifteen hydrocarbons to native DNA has been investigated. The hydrocarbons were chosen to test a size criterion for hydrocarbon - DNA complexes. It has been found that hydrocarbons, which are small enough to intercalate between the base pairs of a distorted Watson - Crick model of DNA, bind to DNA. No binding was found for hydrocarbons which cannot slip between base pairs, with no appreciable contact with the aqueous medium. Those hydrocarbons which bind, do so in a monomolecular fashion, as judged by the absence of excimer emission. The results are consistent with the intercalation model of binding and offer support for it.
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  • File scanned at 300 ppi using Capture Perfect 3.0 on a Canon DR-9050C in PDF format. CVista PdfCompressor 5.0 was used for pdf compression and textual OCR.
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