Size criterion for intercalation of hydrocarbon in DNA

Graduate Thesis Or Dissertation

Public Deposited

Citeable URL: https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/vh53x060x

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Attribute Name	Values
Creator	Craig, Albert Morrie
Abstract	The binding of fifteen hydrocarbons to native DNA has been investigated. The hydrocarbons were chosen to test a size criterion for hydrocarbon - DNA complexes. It has been found that hydrocarbons, which are small enough to intercalate between the base pairs of a distorted Watson - Crick model of DNA, bind to DNA. No binding was found for hydrocarbons which cannot slip between base pairs, with no appreciable contact with the aqueous medium. Those hydrocarbons which bind, do so in a monomolecular fashion, as judged by the absence of excimer emission. The results are consistent with the intercalation model of binding and offer support for it.
Resource Type	Masters Thesis
Date Available	2014-04-09T17:17:38+00:00
Date Issued	1968-04-25
Degree Level	Master's
Degree Name	Master of Arts (M.A.)
Degree Field	Biochemistry and Biophysics
Degree Grantor	Oregon State University
Commencement Year	1968
Advisor	Isenberg, I.
Academic Affiliation	Biochemistry and Biophysics
Non-Academic Affiliation	Oregon State University. Graduate School
Subject	DNA
Rights Statement	Copyright Not Evaluated
Publisher	Oregon State University
Peer Reviewed	No
Language	English [eng]
Digitization Specifications	File scanned at 300 ppi using Capture Perfect 3.0 on a Canon DR-9050C in PDF format. CVista PdfCompressor 5.0 was used for pdf compression and textual OCR.
Replaces	http://hdl.handle.net/1957/47183

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