Large volume (1,800 µL) injection HPLC/MS/MS for the quantitative determination of illicit drugs and human urinary biomarkers in municipal wastewater Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/vt150m25w

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  • A sensitive, selective, rapid analytical method based on large-volume injection (LVI) liquid chromatography/ tandem mass spectrometry was developed using commercially-available hardware that eliminates the need for either off-line or on-line solid phase extraction. Centrifugation followed by the direct injection of 1,800 µL was used for the quantification of illicit drugs, metabolites, and human urinary biomarkers in municipal wastewaters. The accuracy of the method as indicated by standard addition was calculated for analytes with concentrations ranging from 4 to 3,500,000 ng/L. The average precision of the method, as indicated by relative standard deviation is 7%. Detection limits range from 2.5 ng/L to 250 ng/L. As a demonstration of the method, the temporal trend in illicit drugs, selected metabolites and human urinary biomarkers was determined for 24-hr flow-normalized composite samples of raw influent collected from a single municipal wastewater treatment plant over the course of three weeks.
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