Graduate Thesis Or Dissertation
 

The effect of egg consumption on cholesterol distribution among lipoproteins and the ratio of Apo A-I/A-II in hyper and hyporesponders

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  • The effect of increased egg consumption on plasma cholesterol levels and its distribution among lipoproteins and Apolipoprotein A-I/A-II ratios of high density lipoprotein subfractions in individuals who did and did not demonstrate response in plasma cholesterol levels was studied in 20 healthy middle-aged men (30-55 years of age) for three months. Lunch containing 3 eggs was fed all subjects during the first month classification period. Subsequently, subjects were divided into hyper and hyporesponders according to their blood cholesterol level. Thereafter, 6 eggs were fed to hypo (n=12) while hyper (n=8) continued to consume 3 eggs with lunch. The average plasma cholesterol level of the 20 subjects was increased from 185±34 to 195±34 mg/lOOml during the classification period. The mean plasma cholesterol level of the hyperresponders was significantly (p<0.025) increased from 170±42 to 199±40 mg/100ml during classification while that of the hyporesponders fell slightly. The additional 6 eggs consumed by the hyporesponders for 6 weeks did not increase the mean plasma cholesterol level. The apoprotein ratios did not change as a result of the increased cholesterol diet and were not significantly different between the two response groups. The hyper and hyporesponders differed significantly in initial plasma cholesterol parameters that diminished as the subjects were challenged with increased cholesterol consumption. These initial differences included a significantly lower low density lipoprotein cholesterol/high density lipoprotein cholesterol ratio of 2.26±0.6 for hyperresponders compared to 3.31±0.9 for hyporesponders. There were also initial differences in the percentage of whole plasma cholesterol found in the HDL fractions: hyperresponders had a greater percentage of total and free cholesterol in the HDL and HDL-2 fractions and a greater percentage of total cholesterol in the HDL-3 fraction. The present data demonstrate that increased cholesterol consumption will increase plasma cholesterol levels and that there is individual variability of plasma cholesterol response as a result of feeding cholesterol.
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