Graduate Thesis Or Dissertation

 

Effects of pH, temperature, concentration, and time on particle counts in lipid-containing TPN admixtures Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/xk81jn59f

Descriptions

Attribute NameValues
Creator
Abstract
  • It has been standard practice in the United States to separate lipid emulsions from the other components of total parenteral nutrition due to the reported instability of admixed intravenous lipid emulsions. Some clinicians, however, have combined all TPN components into one container and administered these admixtures to patients without apparent difficulties. Infusion of all nutrients from one container has many advantages. In this study, standard and concentrated admixtures were aseptically prepared using generally accepted guidelines of the nutritional requirements for a 70 Kg patient. Treatments of standard and concentrated admixtures consisted of: 1) storing at 40°C without ad)usting the pH; 2) increasing the pH to 6.6 and storing at 40°C; 3) increasing the pH to 6.6 and storing at room temperature. Samples were monitored for three weeks by means of Coulter Counter analysis, pH determinations, and visual observations. The pH of the admixtures did not change over three weeks. Mean particle counts increased over time for each treatment group. Within treatments, concentrated admixtures had significantly greater particle counts than the corresponding standard admixtures. Within the standard and within the concentrated admixtures, the particle counts were significantly greater for group one than for group three. Particle counts in group two tended to lie between the values of group one and three. Visual signs of emulsion deterioration were greatest in those admixtures in which the pH was not adjusted and occurred earlier in concentrated admixtures.
Resource Type
Date Available
Date Copyright
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi (Monochrome) using ScandAll PRO 1.8.1 on a Fi-6770A in PDF format. CVista PdfCompressor 5.0 was used for pdf compression and textual OCR.
Replaces
Additional Information
  • description.provenance : Submitted by Sergio Trujillo (jstscanner@gmail.com) on 2013-07-12T20:02:08Z No. of bitstreams: 1 BettnerFrancoiseSoges1985.pdf: 276111 bytes, checksum: 5d5fcfdde8844ab3dae2ebfd1fb3f31f (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2013-07-16T14:38:27Z (GMT) No. of bitstreams: 1 BettnerFrancoiseSoges1985.pdf: 276111 bytes, checksum: 5d5fcfdde8844ab3dae2ebfd1fb3f31f (MD5)
  • description.provenance : Made available in DSpace on 2013-07-19T20:58:40Z (GMT). No. of bitstreams: 1 BettnerFrancoiseSoges1985.pdf: 276111 bytes, checksum: 5d5fcfdde8844ab3dae2ebfd1fb3f31f (MD5) Previous issue date: 1984-11-29
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2013-07-19T20:58:40Z (GMT) No. of bitstreams: 1 BettnerFrancoiseSoges1985.pdf: 276111 bytes, checksum: 5d5fcfdde8844ab3dae2ebfd1fb3f31f (MD5)

Relationships

Parents:

This work has no parents.

Items