The effect of dimethyl sulfoxide (DMSO) on the radiosensitivity of the rough-skinned newt (Taricha granulosa) Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/xp68kk994

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  • More than 2,000 male newts were collected during the summer and maintained unfed at 10°C both pre- and post-irradiation. Exposures ranging up to 30 kR were given with 300 kVp X-rays and ⁶⁰Co gamma rays. Half of the newts were injected (I. P.) with 15 g DMSO/kg (the maximum sublethal dose) just before exposure. The remainder were irradiated without treatment. The mean survival time-exposure curves for both groups of animals were typically sigmoid. However, the mean survival times of the DMSO-treated newts were significantly longer for all exposures between 200 R and 15 kR. The threshold lethal dose for the untreated newts was 200 R, while at exposures up to 600 R the DMSO-treated animals showed a mean survival time not significantly different from the fasting controls (370 days). A dose-reduction factor of 2.45 was calculated for the time presumed to represent the predominant phase of the hematopoietic syndrome (200 days). Additional studies revealed a linear relationship between the concentration of DMSO administered and the degree of radioprotection afforded and demonstrated clearly that DMSO must be administered prior to irradiation to be protective. Marked changes in the physiological status of the DMSO-treated newts were observed which may partially account for their reduced radiosensitivity. DMSO-treated newts showed a decreased metabolic rate during the early post-injection period. Their red blood cell count underwent a dramatic increase, while untreated newts displayed the typical post-irradiation anemia. DMSO also appeared to prevent the visible skin ulcerations following irradiation commonly observed in the non-treated newts.
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  • description.provenance : Approved for entry into archive by Katy Davis(kdscannerosu@gmail.com) on 2014-03-04T19:00:13Z (GMT) No. of bitstreams: 1 LappenbuschWilliamL1969.pdf: 3791985 bytes, checksum: 63056fc243dc578ac6905ab1f3a89bcc (MD5)
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