The effects of whole body vibration on bone recovery following hindlimb unloading of adult female rats Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/xs55mf995

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  • Introduction: A bone deficit is found to persist five years following a hip fracture and 10 years post tibial fracture in adults. We examined the effect of whole body vibration (Vib) as a means for enhancing whole body composition and bone recovery following hindlimb unloading (HU) of adult female rats. Methods: Seven-month-old female Fischer 344 rats (two control and three experimental groups, n= 10 per group) were used in the study. The experimental groups were HU for 15 days, followed by a return to either weight bearing (HU + WB) or 10 min./day of whole body vibration (HU + Vib) for nine days. Body weight, food weight, whole body composition, and dynamic and static histomorphometric analyses of the proximal tibia metaphysis were measured. A t-test was used for comparisons during HU, while ANOVA followed by a post-hoc test was used with the recovery groups. Results: Unloading resulted in lower body weight, fat mass, total bone area, total bone mineral content (BMC), and suppressed bone formation parameters in cancellous bone of the tibia. Following nine days of recovery, the HU + WB and HU + Vib groups had lower body weight and fat mass compared to the control group. The HU + Vib group had lower total bone area, while the HU + WB group had a trend (p < 0.10) for lower total bone area compared to the control group. While there were no differences between recovery groups for BMC, the HU + Vib rats did have suppressed tibial Oc.Pm/B.Pm compared to the control group. Conclusion: Whole body vibration may enhance bone recovery by suppressing bone resorption.
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