Graduate Thesis Or Dissertation
 

Effect of altered carbohydrate diet, vitamin B-6 supplementation, and exercise on vitamin B-6 metabolism in trained and untrained women

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  • This investigation was designed to add to present understanding of vitamin B-6 (B6) metabolism during exercise. Ten women, 5 aerobically trained and 5 untrained, were fed 4 controlled diets: a moderate carbohydrate (49%) (MCHO) for 2 weeks, a high carbohydrate (63%) (HCHO) for one week, MCH0+B6 for 2 weeks, and HCH0+B6 for 1 week. A one week MCHO diet separated the non-supplemented (2.3 mg B6) and supplemented (10.3 mg B6) diets. The V02 max of each subject was determined prior to the study. An exercise test was completed on day 5 or 6 of weeks 2, 3, 6, and 7. The test consisted of 20 minutes of cycle ergometer exercise at 80% V02 max, preceded by 10 minutes of warm-up and followed by a 5-10 minute active recovery. Blood samples were collected pre exercise (pre), 2-3 minutes post (post), 30 minutes post (p30), and 60 minutes post (p60) exercise. Samples were analyzed for plasma vitamin B-6 (PB6), hematocrit, and hemoglobin. Urine was collected daily in 24-hr aliquots and samples were analyzed for 4-pyridoxic acid (4PA) and creatinine. For all diets, exercise resulted in a significant increase in PB6 from pre to post and a significant decrease from post to p60, the magnitude of the change being greater with supplementation. PB6 fell below pre levels by p60 for all exercise sessions. 4PA increased significantly from the day before exercise to the day of exercise on all diets. There was no significant effect of dietary carbohydrate on levels of PB6 or excretion of 4PA. ANOVA showed no difference between the groups for PB6 or 4PA, though the trained group had lower PBS and greater 4PA excretion throughout the study despite the controlled intake. Tissue redistribution of B6 seems to occur with exercise. The increased magnitude of change in PB6 with exercise after supplementation suggests an increased storage of the vitamin, most likely associated with glycogen phosphorylase in the muscle. Trained women may have lower levels of PB6 and greater 4PA excretion as the result of a regular exercise program. However, supplementation with B6 cannot be recommended since the status of all subjects was adequate with the diet fed.
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