Graduate Thesis Or Dissertation
 

Formulation of an oral acetylsalicylic acid suspension and pharmacokinetics of parenteral thrombomodulin analogues

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/z890rx30j

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  • Sustained concentrations of active compound were maintained in vitro and in vivo for an oral and a parenteral dosage form respectively. The vehicle of a oral dosage form was modified and the molecular structure of a parenteral dosage form was modified. An oral dosage form was tested in vitro using dissolution apparatus. A parenteral dosage form was tested in vivo using rats. A new oral suspension dosage form for acetylsalicylic acid was compared to two controlled release forms and two immediate release dosage forms which are currently commercially available. A parenteral thrombomodulin analogue conjugated to polyethylene glycol was compared to the unconjugated thrombomodulin analogue. In each case the goal was to maintain sustained concentrations of active compound.
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  • File scanned at 300 ppi (Monochrome) using ScandAll PRO 1.8.1 on a Fi-6770A in PDF format. CVista PdfCompressor 5.0 was used for pdf compression and textual OCR.
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file details PiepmeierEdwardHJr1991.pdf 2017-08-15 Público Descargar