Honors College Thesis
 

Identification of a Bioactive Aryl Ether from a South African Tunicate

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https://ir.library.oregonstate.edu/concern/honors_college_theses/1257b0303

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  • Chemical compounds produced by organisms, or natural products, are excellent sources of inspiration for anticancer pharmaceutical discovery (Rodrigues et al., 2016). Microtubule targeting agents are a specific class of compounds, often discovered from natural sources, that have been developed as clinically successful anticancer therapies (Steinmetz and Prota, 2018). In the present study, we investigated the biological activity of vitilevuamide, a marine natural product recently rediscovered and isolated from South African tunicates. We confirmed the mechanistic basis of vitilevuamide activity as a tubulin destabilizer. However, there were eight additional compounds present in early samples of vitilevuamide. With access to repurified samples of vitilevuamide, and the individual contaminants, we determined that the associated aryl ethers were unlikely to account for the bioactivity of vitilevuamide. However, one compound, B33B, showed moderate bioactivity as a single entity, albeit at a potency 16.6 times less than vitilevuamide. The activity of B33B alone was confirmed by the study of several human cancer cells lines and through morphological analysis of cells treated with the compound.
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  • Ongoing Research
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  • 2020-03-23 to 2022-04-24

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