Honors College Thesis
 

Supernatant of MAH-infected macrophages suppresses the ability of uninfected macrophages to kill intracellular bacteria

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  • Mycobacterium avium subsp. hominissuis (MAH) is a nontuberculous mycobacterium which commonly infects patients with underlying lung pathology. MAH infections are difficult to treat and require lengthy courses of multiple antibiotics. MAH infects macrophages and evade the immune system by altering host cell cytokine production. The hypothesis is that intracellular MAH may influence communication between infected and surrounding uninfected macrophages, acting to impair macrophage killing mechanisms and increase the chance of bacterial survival. Our results confirm that MAH-infected macrophages secrete regulatory molecules that suppress the bacterial killing-ability of neighboring, uninfected macrophages. Evidence indicates that the molecules of interest are likely small, labile proteins in the 10-30 kDa size range. The molecules showed no influence in the uptake of E. coli or MAH by macrophages. Understanding the underlying mechanisms is of great importance and will help improve the management of MAH infections in humans.
  • Keywords: Mycobacterium avium subsp. hominissuis, pathogenesis, suppression, macrophage, MAC
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