Exploring the Synthesis of 4-Deoxygadusol

Honors College Thesis

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Citeable URL: https://ir.library.oregonstate.edu/concern/honors_college_theses/2f75rf06h

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Attribute Name	Values
Creator	Jujjuri, Anantha Poojitha
Abstract	Sunscreen products are used worldwide to protect the skin from ultraviolet radiation. However, some of the ingredients used in sunscreen products are fatal to coral reefs especially in areas where tourism is a large part of the economy. In this study, we explored a synthetic route to produce 4-deoxygadusol, which is a core unit of mycosporine-like Amino Acid (MAAs). MAAs are found in bacteria, fungi, algae and marine invertebrates. It has been proposed that MAAs fulfill functions such as sunscreen, antioxidant and stress response. MAAs work by a mechanism which absorbs UV radiation and converts it into heat without the formation of free oxygen species and without posing a threat to coral reefs. Two competing synthetic schemes to 4-deoxygadusol were explored, and three out of the proposed eight to nine synthetic steps have been accomplished. The products were verified using NMR and mass spectrometry.
License	Attribution 4.0 (CC BY 4.0)
Resource Type	Honors College Thesis
Date Issued	2018-05-31
Degree Level	Bachelor's
Degree Name	Honors Bachelor of Science (H.B.S.)
Degree Field	Microbiology
Degree Grantor	Oregon State University
Commencement Year	2018
Advisor	Mahmud, Taifo
Committee Member	Philmus, Benjamin Blakemore, Paul R.
Non-Academic Affiliation	Oregon State University. Honors College
Declaração de direitos	In Copyright
Publisher	Oregon State University
Peer Reviewed	No
Language	English [eng]

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Miniatura	Título	Data de carga	Acesso	Ações
	JujjuriAnanthaP2018.pdf	2018-06-10	Público	Baixar