Honors College Thesis

 

Integrating Microfluidics and Integrated Circuits toward a CMOS-Based Cell Counter Public Deposited

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https://ir.library.oregonstate.edu/concern/honors_college_theses/2n49t704q

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  • Cell counting is a key tool used in biological and clinical laboratories, but at present, commercial cell counters are large and expensive. CMOS technology is a promising platform for creating small, low-cost sensors but currently lacks a robust method of directly interfacing these sensors with the microfluidic networks needed for sample delivery. We present two methods of microfluidic integration. The first is a laser-cut fabrication method for rapid prototyping of devices; it uses only standard ‘maker’ tools and a completed device can be fabricated in under one hour. The second, higher resolution, method uses photolithography to define SU-8 channels that can be created on the scale of single cells. A method of planar, metallized electrical connections to the IC is also described that can implemented with either fluidic method above. A completed device shows that leak-free channels can route fluid directly over a SPAD light sensor with metal connections, representing an important milestone toward a fully-integrated CMOS-based cell counter.
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  • Funded in part by Oregon State University Honors College DeLoach Work Scholarship
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