Honors College Thesis


Analysis of SNPs in Mycoplasma cynos strains from canine hosts within the Pacific Coast animal shelter network Public Deposited

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  • Single nucleotide polymorphisms (SNPs) can be used as markers to infer population genetic structure. For Mycoplasma cynos, a pathogen associated with infectious respiratory disease among canines and other animals, SNPs may help to elucidate ecological and evolutionary relationships among the strains that reside in the upper respiratory tract of canines and that circulate within a network of animal shelters. When hosts are transferred within a network and expose their microbiomes to different environments, the pathogens contained within the microbiome can accumulate single nucleotide mutations from environmental effects. The present study looks at SNPs at positions across the entire M. cynos genome using data from high throughput short-read sequences recovered from nasal swabs. The swabs came from five canines sampled from an animal shelter that regularly receives transfers from other locations. Results from the analysis of the SNPs indicates evidence of genetic structure among M. cynos populations resident within each sampled canine. This heterogeneity may be indicative of a variety of processes across different scales which can shape microbial biogeography in networks of hosts.
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