Honors College Thesis

 

Investigating the age-related loss of endoplasmic reticulum stress response Public

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  • The endoplasmic reticulum (ER) is a crucial organelle in the cell where protein folding and processing occurs, and conditions that negatively affect ER functions are highly detrimental to the cell. The accumulation of unfolded/misfolded proteins in the ER leads to a condition known as ER Stress. The ER has developed various pro-survival and pro-apoptosis signaling pathways that attempt to cope with this stress. ER stress is relevant to many clinical studies and has been linked to a variety of age-related diseases, including Huntington’s, Alzheimer’s, Parkinson’s and heart disease. Despite these findings, the manner in which ER stress response is altered with age hasn’t been thoroughly studied and constitutes a gap in knowledge. In this study, we investigated the age-related loss of ER stress response in young and old rats. Our results suggest that, in both young and old cells, the pro-apoptosis pathway which utilizes the transcription factor, CHOP, remains intact with age. However, the pro-survival pathway acting through PERK/Nrf2 and the phase II detoxification enzyme NQO1 show elevated activity in the young cells, but a loss of function in the old. These results suggest that stresses which would not cause cell death in young individuals may induce cell death in the elderly.
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  • description.provenance : Submitted by Heather Boren (borenh) on 2007-08-06T20:58:19ZNo. of bitstreams: 2Fallechi Thesis 9.doc: 497152 bytes, checksum: cf45e9047b14d10c38591c1f89267592 (MD5)Fallechi Pre-Text.doc: 57344 bytes, checksum: 1f86c3c1faea0f76febd678da43ff3fc (MD5)
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