Honors College Thesis

 

Investigating the age-related loss of endoplasmic reticulum stress response Public Deposited

Analytics

Downloadable Content

Download file
https://ir.library.oregonstate.edu/concern/honors_college_theses/cr56n3047

Descriptions

Attribute NameValues
Creator
Abstract
  • The endoplasmic reticulum (ER) is a crucial organelle in the cell where protein folding and processing occurs, and conditions that negatively affect ER functions are highly detrimental to the cell. The accumulation of unfolded/misfolded proteins in the ER leads to a condition known as ER Stress. The ER has developed various pro-survival and pro-apoptosis signaling pathways that attempt to cope with this stress. ER stress is relevant to many clinical studies and has been linked to a variety of age-related diseases, including Huntington’s, Alzheimer’s, Parkinson’s and heart disease. Despite these findings, the manner in which ER stress response is altered with age hasn’t been thoroughly studied and constitutes a gap in knowledge. In this study, we investigated the age-related loss of ER stress response in young and old rats. Our results suggest that, in both young and old cells, the pro-apoptosis pathway which utilizes the transcription factor, CHOP, remains intact with age. However, the pro-survival pathway acting through PERK/Nrf2 and the phase II detoxification enzyme NQO1 show elevated activity in the young cells, but a loss of function in the old. These results suggest that stresses which would not cause cell death in young individuals may induce cell death in the elderly.
License
Resource Type
Date Available
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Committee Member
Non-Academic Affiliation
Rights Statement
Publisher
Peer Reviewed
Language
File Format
File Extent
  • 57344 bytes
  • 497152 bytes
Replaces
Additional Information
  • description.provenance : Submitted by Heather Boren (borenh) on 2007-08-06T20:58:19ZNo. of bitstreams: 2Fallechi Thesis 9.doc: 497152 bytes, checksum: cf45e9047b14d10c38591c1f89267592 (MD5)Fallechi Pre-Text.doc: 57344 bytes, checksum: 1f86c3c1faea0f76febd678da43ff3fc (MD5)
  • description.provenance : Made available in DSpace on 2007-08-06T23:25:35Z (GMT). No. of bitstreams: 2Fallechi Thesis 9.doc: 497152 bytes, checksum: cf45e9047b14d10c38591c1f89267592 (MD5)Fallechi Pre-Text.doc: 57344 bytes, checksum: 1f86c3c1faea0f76febd678da43ff3fc (MD5)

Relationships

Parents:

This work has no parents.

In Collection:

Items

Thumbnail Title Date Uploaded Visibility Actions
3n204156c?file=thumbnail Fallechi Pre-Text.doc 07/27/2017 Public
6w924d67r?file=thumbnail Fallechi Thesis 9.doc 07/27/2017 Public
1z40m001r?file=thumbnail Fallechi_Thesis_9.pdf 2018-07-12 Public