Honors College Thesis
 

Anti-inflammatory effects of minor cannabinoids from hemp

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  • Cannabis sativa (C. sativa) is a widely used plant with applications in medicine, textiles, food, and industry. Among its bioactive compounds, cannabinoids have gained significant attention for their therapeutic potential. This study aimed to investigate the anti-inflammatory properties of minor cannabinoids extracted from the mother liquor, a byproduct of cannabinoid crystallization. 47 minor cannabinoid fractions were tested for their ability to reduce inflammation in RAW 264.7 mouse cells. An inflammatory response was induced in the cells using lipopolysaccharide (LPS). The effectiveness of the fractions in reducing inflammation was assessed using a Griess assay for nitric oxide (NO) production and an interleukin-6 (IL-6) Enzyme-Linked Immunosorbent Assay (ELISA) to measure IL-6 concentrations. The Griess assay results demonstrated successful inflammation responses induced by LPS in the cells. The ELISA assay results showed variation in IL-6 reduction within the different fractions with some showing reduced IL-6 levels compared to LPS-treated controls. These findings suggest that specific minor cannabinoids possess anti-inflammatory properties which supports their potential use in pharmaceutical applications.
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  • 27 pages
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file details Kelly Nguyen2025.pdf 2025-03-11 Público Baixar