Honors College Thesis
 

Effects of Bacterial Redox Stressors on the Environmental Stability of Influenza A

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https://ir.library.oregonstate.edu/concern/honors_college_theses/gh93h753x

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  • It is becoming increasingly apparent that the human microbiome plays an important role in regulating disease progression. Evidence uncovered in the last half-decade suggests that this role may extend to the regulation of influenza A infections through many as yet unexplored interactions. Recent studies on the pathogenesis of influenza A (IAV) have uncovered previously undetected direct interactions between the virus and members of the microbiome that aid in the propagation of an infection. If members of the microbiome are capable of altering viability of Influenza A under environmental and immune-induced stress conditions, they may be able to aid in the human-to-human transmission of an infection as well as the propagation of an infection within a single host. In this investigation we explore how oxidative stress from both the environment and the metabolic activity of bacteria found in the human respiratory microbiome contribute to the stabilization of Influenza A in the event of co-deposition of both bacterial cells and viral particles in respiratory droplets on an indoor surface. We also find that reducing peroxide production by S. pneumoniae confers protection for IAV in the event of desiccation in the environment.
  • Keywords: Bacteria, Microbiome, Streptococcus, Staphylococcus, virus, Influenza, Redox, Transmission
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  • This work was supported in part by the Beginning Researcher Support Program and the Continuing Researcher Support Program within the College of Agricultural Sciences at Oregon State University.
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