Honors College Thesis

 

Optimizing Methods to Assess Nanoparticle Biodistribution in Embryonic Zebrafish Public Deposited

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https://ir.library.oregonstate.edu/concern/honors_college_theses/hd76s515h

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  • As nanoparticle (NP) research and development expands, the significance of NP biodistribution effects on toxicity increases. A reliable method for measuring NP biodistribution is critical. Hyperspectral Imaging (HSI) is capable of accurately quantitating NP biodistribution within embryonic zebrafish with incredibly high precision. Before HSI processing, the embryo must be sectioned on the micrometer scale to promote HSI image clarity. The embryo sectioning process, as the intermediate between the completion of the NP exposure assay and HSI, significantly impacts the quality of HSI analysis. This Cryostat zebrafish embryo sectioning methodology has been optimized and preliminary HSI analysis suggests positive results for measuring NP biodistribution.
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