Honors College Thesis
 

The Relationship Between Gestational Diabetes and the Risk of Orofacial Clefts in Infants: A Systematic Review

Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/honors_college_theses/mp48sm626

Descriptions

Attribute NameValues
Creator
Abstract
  • Background: This study investigated the relationship between gestational diabetes mellitus (GDM) and orofacial cleft (OFC). The association between GDM and OFC has been debated, therefore this systematic review focused on presenting a synthesis of the previous studies in this field. Methods: PubMed was searched using MeSH terms for articles published through February 28th, 2021. Retained studies were then examined to retrieve quantitative and qualitative data to draw comparisons and analyze the association between GDM and OFC. Results: Among the 418 articles that were obtained from PubMed, eight articles met the inclusion criteria. The retained articles included four case-control studies, three cohort studies, and one cross-sectional study. Four of the studies reported the presence of a weak association between GDM and OFC (OR range: 1.40-1.60), while the other four studies reported no association between the two variables. Three of the four case-control studies reported weak, but significant associations. In contrast, only one cohort study reported an association between GDM and OFC, but only when mothers with GDM were also obese. Conclusion: This review found no evidence of an association between GDM and OFC. This study highlights the lack of research conducted on the relationship between these variables and calls for further investigative studies.
  • Key Words: Gestational diabetes, Orofacial clefts, Cleft lip with or without palate, Cleft palate, Systematic review
Resource Type
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Committee Member
Non-Academic Affiliation
Rights Statement
Publisher
Peer Reviewed
Language

Relationships

Parents:

This work has no parents.

In Collection:

Items

Thumbnail Title Date Uploaded Visibility Actions
file details KutcherDrewA2021.pdf 2021-06-01 Public Download