Honors College Thesis


Roles of Innate Lymphoid Cells on Mycobacterium avium infection Public Deposited

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  • Mycobacterium avium subsp. hominissuis (MAH) is a common environmental bacterium that causes infections in immunocompromised patients such as those with HIV/AIDS, or patients with chronic lung disease such as Cystic Fibrosis. There are many strains of MAH with varying levels of virulence. Infection with MAH strains 100 and 104 have been associated with different immune responses in mice. While MAH 100 infection tends to be cleared from mice, MAH 104 has a greater virulence and grows in host tissue. What is currently unknown are the mechanisms related to this difference in host defense and virulence. Our hypothesis is that differences in submucosa innate lymphocytes response are associated with increased protection from infection. Innate Lymphoid Cells (ILC) are lymphoid cells with an important role in regulation of innate immune systems. ILCs can be categorized into three subpopulations ILC 1, ILC 2, and ILC 3 based on their cytokine production. Investigation was carried out on how macrophage anti-MAH response changes depending on activation by primary mouse lymphocytes belonging to different ILC subpopulations. Our results do not affirm the role of any one ILC subpopulation in macrophage anti-M. avium ability. Our findings instead support the conclusion that mycobacterium infected macrophages suppress the stimulatory function of ILCs.
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