Honors College Thesis
 

Depression classification of the patients in meta-analyses studies affects the efficacy of St. John's wort

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  • Eight studies from a meta-analysis on St. John's wort by Klaus et. al. (1996) were analyzed according to the severity of depression manifest by their patients. The studies were chosen according to inclusion criteria: 1) the study was random, 2) the study compared St. John's wort to a placebo or an antidepressant, 3) the study was controlled, 4) the study clearly stated the level of severity of depression demonstrated by subjects, and 5) the subjects were homogeneous for level of severity. The studies were then analyzed to determine whether the depression classification had an affect on the efficacy of St. John's wort. The Mantel-Haenszel test indicated that when the depression classification is major depression, the odds of improving for the St. John's wort group is greater than that of the placebo group, and to a lesser extent, the antidepressant group. The results indicated that the depression classification of the patients in the studies does affect the efficacy of St. John's wort in the meta-analysis of Klaus et. al. 1996.
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