Quantification of Propofol in Blood Plasma and its Application to Future Clinical Research in Anesthesiology and Perioperative Medicine

Honors College Thesis

Pubblico Deposited

Citeable URL: https://ir.library.oregonstate.edu/concern/honors_college_theses/v405sj10b

Descriptions

Attribute Name	Values
Creator	Bemis, David J.
Abstract	High Performance Liquid Chromatography-Mass Spectrometry coupled with filtration, centrifugation, and other common sample preparation techniques offers a rapid and robust method for separating and quantifying propofol, a commonly used anesthetic, from human blood and its synthetic analogs. Method development is important for not only optimizing separation and quantification for a sample in a given matrix, but also for doing so on a specific instrument. The first part of thesis focuses on this method development by determining or offering the experimental framework to determine optimal detection wavelength, flowrate, instrument (i.e. nano versus conventional HPLC), and mobile phase. The second part applies this technique to assess if alcoholic liver disease affects the minimum effective dose, recovery time, and depth of sedation in intensive care unit patients receiving propofol to be intubated due to alcohol withdrawal.
Resource Type	Honors College Thesis
Date Issued	2021-02-09
Degree Level	Bachelor's
Degree Name	Honors Bachelor of Science (H.B.S.)
Degree Field	Microbiology
Degree Grantor	Oregon State University
Commencement Year	2021
Advisor	Remcho, Vincent T.
Committee Member	Rinaldi, Phillip Bruslind, Linda
Non-Academic Affiliation	Oregon State University. Honors College
Dichiarazione dei diritti	In Copyright
Publisher	Oregon State University
Peer Reviewed	No
Language	English [eng]

Parents:

This work has no parents.

In Collection:

Thumbnail	Titolo	Data caricata	Visibilità	Azioni
	BemisDavidJ2021.pdf	2021-02-25	Pubblico	Scaricare