- BACKGROUND: The association of vitamin D with heart attack and stroke remains unclear.
METHOD: Using data from the Osteoporotic Fractures in Men Study (MrOS), we collected
dietary vitamin D data from 5,995 participants and serum (25)OH vitamin D from 1,606
participants. The association of vitamin D with prevalent heart attack and strokes was studied
using an unconditional logistic regression model. Then, incidence of heart attack and stroke was
prospectively studied using a log binomial model. RESULTS: In the analysis of prevalence, a
non-significant inverse relationship between vitamin D and heart attack and stroke was observed.
However, participants in the highest quartile of dietary vitamin D reported significantly fewer
prevalent strokes than men in the lowest quartile (prevalence ratio, 0.72; p=0.04). In the
incidence analysis, the data was largely inconclusive. In the dietary vitamin D analyses, the
highest quartile dietary vitamin D was generally associated with a non-significant decreased odds
of heart attack (odds ratio, 0.98; p=0.91) and stroke (odds ratio 0.97; p=0.98). Similarly, in the
serum analysis, the highest quartile of serum vitamin was associated with a non-significant
decreased odds of heart attack (odds ratio, 0.82; p=0.49) and stroke (odds ratio 0.57; p=0.10).
CONCLUSION: Vitamin D was not significantly protective against incidents of heart attack and
stroke. While the majority of our results showed a minor protective effect, it was too small to
make definitive conclusions.