- Feline upper respiratory tract disease (FURTD) is a complex syndrome that affects domestic cats, with clinical signs including general malaise, ocular and nasal discharge, and oral pathology. Our study compared the presence or absence of five common FURTD pathogens and routine blood parameters between 18 participating cats. Owners tended to underreport FURTD signs, particularly oral pathology. Additionally, several cats that displayed clear FURTD signs tested negative for common FURTD pathogens, while two cats that did not have any owner-reported signs tested positive. Clinically ill cats had a suggestively higher neutrophil count (n = 17, p = 0.0081) and neutrophil-lymphocyte ratio (n = 18, p = 0.048) than clinically healthy cats, although the statistical significance was eliminated after correction for multiple comparisons. Cats that tested positive for at least one respiratory pathogen had a suggestively lower platelet count (n = 13, p = 0.0615) than cats that tested negative for all pathogens. Our findings suggested a weak association between neutrophilia and FURTD, which may potentially aid in early detection of the disease, even in patients with subclinical infections. However, further research with a larger study population may enable the acquisition of more statistically significant findings.