Honors College Thesis
 

Localization of the CB1 receptor in the brain of Taricha granulosa

Público Deposited

Conteúdo disponível para baixar

Baixar PDF
https://ir.library.oregonstate.edu/concern/honors_college_theses/xp68kn19m

Descriptions

Attribute NameValues
Creator
Abstract
  • The psychoactive component of marijuana, A9-tetrahydrocannabinol (THC), is known to have effects in humans that are mediated by the cannabinoid receptor (CB 1). Although a great deal of research has been done to confirm the interaction of exogenous cannabinoids with the CB 1 receptor, little is known about the receptor's natural function. Our lab's working hypothesis suggests that the sexual behavior of the male roughskin newt, Taricha granulosa, is regulated by an endogenous cannabinoid signaling system. For the purpose of determining such a mechanism, localization of the CBI receptor in the brain ofT. granulosa is essential. Therefore, immunohistochemistry was used to localize the CB1 receptor in the newt utilizing a primary antibody against the carbonyl-terminus of the rat CB 1 receptor. The study determined the presence of the CB1 receptor throughout the various sub-regions of the telencephalic hemispheres and the diencephalon. The localization of the CB 1 receptor in T. granulosa, not only suggests evolutionary conservation of the receptor distribution, but also provides evidence for an endogenous cannabinoid signaling system in the roughskin newt.
License
Resource Type
Date Available
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Committee Member
Non-Academic Affiliation
Declaração de direitos
Publisher
Peer Reviewed
Language
File Format
File Extent
  • 1492770 bytes
Digitization Specifications
  • Master files scanned at 600 ppi (24-bit Color) using Capture Perfect 3.0 on a Canon DR-9080C in TIF format. PDF derivative scanned at 300 ppi (24-bit Color), using Capture Perfect 3.0, on a Canon DR-9080C. CVista PdfCompressor 3.1 was used for pdf compression and textual OCR.
Replaces

Relações

Parents:
Em Collection:

Itens

Miniatura Título Data de carga Acesso Ações
file details Aubert_Jo.pdf 2017-12-12 Público Baixar