Undergraduate Thesis Or Project
 

HentzeKalina2016 - Thesis.pdf

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https://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/70795897t

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  • Cystic ovarian disease (COD) is one of the main causes of infertility in dairy cattle and has a high economic impact on farmers. COD is caused by an endocrine imbalance within the hypothalamic-pituitary-ovarian axis which prevents the mature Graafian follicle from ovulating. The cause at the molecular level is not well understood. Our research investigated the possibility of using plasma concentrations of matrix metalloproteinases (MMP) -2 and -9 and their natural tissue inhibitors (TIMP) -1 and -2 as prognostic indicators of COD. Plasma samples from cystic and non-cystic dairy cows were analyzed using ELISA. Although plasma concentrations of MMP-2 and -9 were greater and TIMP-2 was lower in non-cystic compared to cystic cows, no significant differences were observed in MMP-2 and -9 and TIMP-1 and -2 due to cyst status. However, the TIMP-1:MMP-9 and TIMP-2:MMP-2 molar ratios were greater, (P=0.099) and (P=0.038), respectively, in cystic compared to non-cystic cows, suggesting a proteolytic insufficiency in cows with COD that may be a contributing factor to the anovulatory pathology. These data may provide the groundwork for future research and development of tools for dairy farmers to selectively choose replacement heifers less likely to develop COD.
  • Keywords: MMP-9, Cystic Ovarian Disease, Follicular Cyst, COD, MMP-2, Bovine Cystic Ovarian Disease, TIMP-2, TIMP-1, Matrix Metalloproteinase
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