LoehrChristianeVeterinary MedicineInfiltrativeMyxomaStifle(Figures1-4).pdf

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Citeable URL: https://ir.library.oregonstate.edu/concern/defaults/ff365617r

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Creator	Loehr, C. V. Hedge, Z. N. Pool, R. R.
Abstract	A 5-year-old, male, domestic rabbit had severe swelling of the left rear leg. Radiographs demonstrated a proliferative, infiltrative lesion involving the stifle joint, femur, and soft tissues of the thigh. Osteomyelitis or neoplasia was suspected, and the leg was surgically amputated. Grossly, a multilobular mass comprised cyst-like structures containing yellow mucinous material. Histologically, the mass formed coalescing lobules of stellate to rounded cells embedded in varying amounts of myxoid to collagenous matrix; some rimmed by narrow walls of metaplastic bone and/or cartilage; some infiltrated with plasma cells, lymphocytes, heterophils and histiocytes. On immunohistochemistry, neoplastic cells stained for vimentin but were negative for cytokeratin, sarcomeric actin, Mac387 and BLA.36. Cytokeratin was not detected in normal synovial cells. Radiographic, gross and histological findings are consistent with synovial myxoma seen in dogs and humans; however, because of extensive involvement of the limb in absence of confirmed metastatic disease, the term infiltrative synovial myxoma was applied.
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