Honors College Thesis
 

Differential Allele Expression of SOD1 in Biomphalaria glabrata

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  • The freshwater snail Biomphalaria glabrata serves as the intermediate host of the blood fluke Schistosoma mansoni. Previous studies using the 13-16-R1 strain of B. glabrata demonstrated an association between the gene encoding Cu/Zn superoxide dismutase (SOD1) and susceptibility/resistance to the parasite. This association is assumed to involve a polymorphism that regulates transcription since individuals possessing the B allele have higher transcript levels of SOD1 than individuals without the B allele. The objective of this project was to determine if SOD1 alleles are differentially expressed in B. glabrata heterozygous hemocytes. This study detected no evidence of allelic imbalance, implying that transcription of SOD1 alleles is likely controlled by a trans-acting regulator (secondary gene) rather than a cis-acting regulator. Keywords: Biomphalaria glabrata, Schistosoma mansoni, SOD1, regulatory polymorphism, differential allele expression Corresponding e-
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