An Accumulation of Senescent Cells May Contribute to Chronic Inflammation of the Mammalian Liver Public

http://ir.library.oregonstate.edu/concern/honors_college_theses/1z40kv91x

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  • The aging process is a biological phenomenon in mammals that heavily contributes to the onset of chronic diseases. While there are many theories that attempt to explain the biological onset of aging, one emerging theory involves chronic inflammation. Chronic inflammation has been previously linked to several age-related diseases and is a known driver of chronic inflammation. To examine chronic inflammation and cellular senescence in the context of aging, we examined hepatocytes harvested from rat livers as a model. We found that rat hepatocytes not only undergo cellular senescence, but that senescent cells accumulate with age. This accumulation of senescent cells with age was also accompanied by a large increase in miR-146a and miR-155 (a seven fold and a forty-five fold change respectively) in the old rat exosomes, which indicate chronic inflammatory insult. These findings corroborate with our findings regarding an accumulation of senescent cells in the liver, and suggests that the liver undergoes an inflammatory stress. We then examined a possible treatment for cellular senescence: the drug known as dasatinib. Key Words: inflammation, aging, senescence, dasatinib, hepatocytes.
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