Isolation, Characterization, and Antibiotic Activity of Fungal Metabolites from an Algal Endophyte Public Deposited

http://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/2514nn63j

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  • Pseudomonas aeruginosa is a gram-negative nosocomial pathogenic bacterium known for its resilience against antibiotics. The bacterium infects over 50,000 patients each year in the United States, with 13% of reported cases involving multi-drug-resistant strains of Pseudomonas. This research discovered several fungal natural products with promising activity against Pseudomonas aeruginosa. The compounds were produced by fungus GOZO23y, an Aspergillus isolated from an algae sample collected near the island of Gozo in the Mediterranean Sea. Bioactivity-guided fractionation of the crude fungal extract by column chromatography and high-performance liquid chromatography led to the isolation of several candidate compounds. Structure elucidation and identification of these molecules was mainly done by 1- and 2-dimensional nuclear magnetic resonance spectroscopy and mass spectrometry supported by natural products databases. Here I present the structures of the isolated compounds from Aspergillus sp. GOZO23y as well as detailed results from the antibacterial screening.
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