redmond The Effect of Sucrose on Respiratory Syncytial Virus.pdf

Undergraduate Thesis Or Project

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Citeable URL: https://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/2f75r952s

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Attribute Name	Values
Creator	Redmond, Jillian
Abstract	Respiratory Syncytial Virus (RSV) is a major concern in infants, the elderly, and immunocompromised individuals. There is currently no vaccine available. While it causes a significant number of hospitalizations and complications, RSV is a thermo labile virus and not very stable in the environment. This matter complicates the creation of a vaccine, which needs to be a stable live-attenuated virus in order to induce a significant immune response. The purpose of this research is to study the effect of sucrose on RSV. Our hypothesis is that sucrose will have a stabilizing effect on the virus. The two objectives of this research are to determine RSV titers using plaque assays and to study the effects of a variety of sucrose concentrations to determine the optimum concentration that has a significant effect on stabilization of the virus. Our data show that the only concentration that was significant was 0.3% sucrose. These experiments will need to be repeated to ensure reproducibility, but remain as a good first step in determining the optimum sucrose concentration for RSV stability. Keywords: Sucrose, Respiratory Syncytial Virus (RSV)
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	redmond_The_Effect_of_Sucrose_on_Respiratory_Syncytial_Virus.pdf	2017-07-27	公开	下载