Undergraduate Thesis Or Project

 

Identifying the role of autophagy in the protection against protein aggregation Public Deposited

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  • Aging is a process that all living species experiences and it also is greatly to study and understand the aging process with the aim of extending human life span. Protein homeostasis is one of the main hall mark of aging. Based on previous data, it observed that cells from long lived species, naked mole rat, have a higher number of autophagy, proteasome activity, and heat shock chaperone proteins that had a higher number of protein aggregation and more resistant to protein aggregation than a short living species, mouse. This led the investigated of weather the autophagy, proteasome activity, or the heat shock chaperone proteins played a role of handle the poly Q protein aggregation. The objective of this work is to investigate the role of autophagy in the protection against polyQ82 toxicity by compare the short and long poly Q aggregation and the complexity.
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  • Funding by the Ray and Frances Cripps Education through a Cripps Undergraduate Research Experience (CURE) stipend from the Department of Biochemistry and Biophysics
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