Synthesis of gold nanoparticle surfactants and their self-assembly at oil-water interfaces Public

http://ir.library.oregonstate.edu/concern/honors_college_theses/3r074x014

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • Amphiphilic gold nanoparticle surfactants can self-assemble at oil-water interfaces to form stable Pickering emulsions. These nanoparticle surfactants have previously been synthesized by functionalizing gold nanoparticles with thiol terminated polyethylene glycol (PEG-thiol), and subsequently with an alkane-thiol. It is necessary to improve the bio-compatibility of the nanoparticles if they are to be used in medical applications. The amino acids L-Cysteine and L-Methionine are already present in the human body and are therefore expected to improve the bio-compatibility of the nanoparticle surfactants when used instead of an alkane-thiol. Similar to the ligands used in previous studies, these amino acids have thiol functional groups that can potentially covalently bond to the gold nanoparticles. Studies were done to develop a method to functionalize these gold nanoparticles with thiol containing amino acids instead of alkane-thiols. Dynamic light scattering (DLS) and UV-Vis experiments were conducted to measure hydrodynamic size and peak absorbance of perfluorohexane (PFH) in water emulsions stabilized by nanoparticle surfactants. Emulsions of PFH in water were successfully stabilized by gold nanoparticle surfactants functionalized with PEG-thiol and L-cysteine. These particle-stabilized emulsions have a tunable plasmon resonance that makes them useful as contrasting agents for medical imaging and for targeted cancer therapy.
License
Resource Type
Date Available
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Non-Academic Affiliation
Rights Statement
Publisher
Peer Reviewed
Language
Replaces
Additional Information
  • description.provenance : Submitted by Kassena Hillman (kassena.hillman@oregonstate.edu) on 2013-06-27T21:51:48ZNo. of bitstreams: 1HC Thesis Mitchell Truong.pdf: 706014 bytes, checksum: ac907a02d8c817c9b626305630930a52 (MD5)
  • description.provenance : Made available in DSpace on 2013-07-10T23:17:14Z (GMT). No. of bitstreams: 1HC Thesis Mitchell Truong.pdf: 706014 bytes, checksum: ac907a02d8c817c9b626305630930a52 (MD5)
  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2013-07-10T23:17:14Z (GMT) No. of bitstreams: 1HC Thesis Mitchell Truong.pdf: 706014 bytes, checksum: ac907a02d8c817c9b626305630930a52 (MD5)

Relationships

Parents:

This work has no parents.

Last modified

Downloadable Content

Download PDF

Items