Pope SeminarUrinary Lipid Biomarkers for Detecting Canine Transitional Cell.pdf

Undergraduate Thesis Or Project

Public Deposited

Citeable URL: https://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/3r0750772

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Attribute Name	Values
Creator	Pope, George
Abstract	Canine Transitional Cell Carcinoma (TCC) makes up 2% of all canine cancers and is the most common cancer of the bladder for dogs. Usually diagnosed in its later stages, TCC is difficult to treat, with low survival times. Current diagnosis involves invasive techniques, and mainstream screening tests are often ineffective. To Identify urinary lipids which could be used as biomarkers, this pilot study used 15 dogs in three cohorts (TCC, Urinary Tract Infection, and Health using a lyophilization lipid extraction method. A total of 208 lipids were identified, and the cohorts were distinguishable by Principle Component Analysis. This study provides evidence to investigate urinary lipids as a biomarker profile for cancers. Keywords: urinary, canine, lipid biomarker, cell carcinoma
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