Vibrio cholerae Response to Environmental Factors Including pH and Salt Content in the Absence of Specific Antiporters Public Deposited

http://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/5712m804w

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  • Vibrio cholerae is a gram-negative gammaproteobacteria, well known for causing the watery-diarrheal disease Cholera. V. cholerae is endemic to the marine and freshwater ecosystems of India and surrounding aquatic environments within that region. Primary reservoirs include brackish water and estuaries. The primary symptom is rapid dehydration due to watery diarrhea. It is a major public health concern for these regions affected as fatality rates range from 50-70% in untreated cases. Here we investigate the adaptability and environmental survival range of V. cholerae by observing the roles of it’s various antiporters. There are 3 primary antiporters in this study: NhaA, NhaB, and NQR. NhaA is a sodium antiporter which exchanges intracellular sodium for extracellular protons at a ratio of 2H⁺:1Na⁺. The other antiporter, NhaB, is slightly less active than NhaA, and exchanges sodium for protons at a rate of 3H⁺:2Na⁺. NQR is not an antiporter, but rather an sodium translocator, using several subunits to directly pump sodium out of the cell. It is the primary tool for environmental adjustment and survival used by V. cholerae. We want to know, what is the role of each of these antiporters in survival of V. cholerae in various environments, including a pH gradient and a cation gradient.
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