Developing the Zebrafish (Danio rerio) As a Model to Evaluate the Toxicity of Chlorinated and Non-Chlorinated Solvents Public Deposited

http://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/6682x8443

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  • Chlorinated and non-chlorinated solvents are used in a variety of industrial processes and as a consequence, they have become environmental contaminants as well. Because of this, they lead to both occupational and environmental exposures. Exposure to these compounds can potentially result in various forms of neurological damage with a wide array of possible mechanisms that are responsible for the resulting neurological deficit. Previous models employed to evaluate these compounds have been the rodent model or studying humans who have been continuously exposed via their occupation. However, these models have their disadvantages so other models need to be explored as possible alternatives to investigate these chemicals. One such model that has been proposed to meet this challenge is the zebrafish (Danio rerio). The zebrafish provides numerous advantages over the other models that have been used in previous research and this project utilized these advantages to study these solvents. The purpose of this study was to determine the validity of the zebrafish as a model to investigate the toxic properties of these solvents. In this study we conducted experiments where zebrafish embryos and adults were exposed to waterborne concentrations of varying concentration and different lengths of time looking at both lethal and sub-lethal effects. We evaluated two chlorinated solvents and three non-chlorinated solvents. All but one of the solvents, 1,2-diacetylbenzene (1,2-DAB), were found to be toxic only at high concentrations.
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