The Effect of Sucrose on the Stability of Respiratory Syncytial Virus Public Deposited

http://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/6969z256s

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  • Respiratory Syncytial Virus (RSV) is a major concern in infants, the elderly, and immunocompromised individuals. There is currently no vaccine available. While it causes a significant number of hospitalizations and complications, RSV is a thermo labile virus and not very stable in the environment. This matter complicates the creation of a vaccine, which needs to be a stable live-attenuated virus in order to induce a significant immune response. The purpose of this research is to study the effect of sucrose on RSV. Our hypothesis is that sucrose will have a stabilizing effect on the virus. The two objectives of this research are to determine RSV titers using plaque assays and to study the effects of a variety of sucrose concentrations to determine the optimum concentration that has a significant effect on stabilization of the virus. Our data show that the only concentration that was significant was 0.3% sucrose. These experiments will need to be repeated to ensure reproducibility, but remain as a good first step in determining the optimum sucrose concentration for RSV stability.
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  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2013-07-18T18:49:11Z (GMT) No. of bitstreams: 2redmond The Effect of Sucrose on Respiratory Syncytial Virus.pdf: 2518889 bytes, checksum: 28e71ab7dc5f1b33b864aa82df990201 (MD5)redmond thesis The Effect of Sucrose on the Stability of Respiratory Syncytial -Final.pdf: 432900 bytes, checksum: b0e87802a3708fbad949f808063e4835 (MD5)
  • description.provenance : Made available in DSpace on 2013-07-18T18:49:11Z (GMT). No. of bitstreams: 2redmond The Effect of Sucrose on Respiratory Syncytial Virus.pdf: 2518889 bytes, checksum: 28e71ab7dc5f1b33b864aa82df990201 (MD5)redmond thesis The Effect of Sucrose on the Stability of Respiratory Syncytial -Final.pdf: 432900 bytes, checksum: b0e87802a3708fbad949f808063e4835 (MD5)
  • description.provenance : Submitted by Wanda Crannell (brr@oregonstate.edu) on 2013-07-17T20:45:22ZNo. of bitstreams: 2redmond The Effect of Sucrose on Respiratory Syncytial Virus.pdf: 2518889 bytes, checksum: 28e71ab7dc5f1b33b864aa82df990201 (MD5)redmond thesis The Effect of Sucrose on the Stability of Respiratory Syncytial -Final.pdf: 432900 bytes, checksum: b0e87802a3708fbad949f808063e4835 (MD5)

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