Immunohistochemical characterization of melanomas in bigenic mice containing activated Cdk4 and keratinocyte specific ablation of Retinoid-X-Receptor alpha (RXRα) protein With international consideration of Differences in Societal and Behavioral Attitudes toward Skin Cancer between Japanese American and Japanese
OVERVIEW OF INTRODUCTION - This is a combined thesis for both disciplines of BioResource Research (BRR)Interdisciplinary and International Degree (ID) Programs OSU. The first chapter encompasses the BRR research, which is a preliminary study utilizing immunohistochemical method to characterize melanomas in bigenic mice with activated Cdk4 protein and Retinoid-X-Receptor α (RXRα). The second chapter is the ID research, which consists of a survey sent to OSU and Akita International University (AIU) to examine the cultural effects on personal preferences in relation to skin cancer.
SUMMARY - Vitamin A deficiency in humans and animal models results in epithelial squamous metaplasia prone to malignant conversion (Curtin et al., 2005). Retinoid, an active vitamin A derivative, can function as a chemo-preventive agent and is important in controlling cell growth, proliferation and differentiation. The Retinoid-X-receptor (RXR) is a central coordinator in mediating the cellular activity of retinoids in vivo. It has been previously shown that the loss of RXRα in epidermal keratinocytes leads to the development of melanocytic nevi. This study investigated the synergistic effect of RXRα ablation and activated Cdk4 in both development and progression of cutaneous melanoma. In combination with activated Cdk4, the melanocytic tumors increase in size and have greater malignant potential.
ABSTRACT - Bachelor of Arts in International Studies in Bioresource Research presented on June 6, 2011. Title: Differences in Societal and Behavioral Attitudes toward Skin Cancer between Japanese American and Japanese The rate of melanoma among Asian American has been steadily increasing in the pastfive years, while in other Asian countries, such as Japan, the incident rate remains relatively the same. Does the culture and societal attitudes toward skin cancer make a difference in the incident rate of melanoma? This survey research investigated this disparity. The populations of interest wereJapanese American and Japanese living in Japan. Skin tone preference, the usage of SPFcontained products, hat and umbrella, skin whitening and tanning products, opinion on white and tanned skin and perceptions on skin cancer were used as premises for comparison. Contrary to the neutral opinions from Japanese American, the majority of Japanese view fondly of white skin over tanned skin.There were some distinct differences in the practice of using umbrella, whitening and tanning skin products. However, there was not a significant difference in the use of SPF-contained products. Additionally, both populations also share similar perceptions about skin cancer. Beauty value generates societal and behavioral attitudes. Since white skin preference is an important aspect valued not just as an esthetic matter but also as an indicator of social class, skin care practice is prioritized in beauty care in Japan. As a result, certain behaviors in skin cancer prevention practices found in native Japanese diverge from Japanese living in other Western countries such as America.The results for this project contribute to the understanding of cultural effects on skin protection and prevention. It has a potentially important role in public health promotion and prevention in America.
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