Effects of 6 months of voluntary alcohol self-administration on intracorticalbone remodeling in young adult male cynomolgus monkeys Public

http://ir.library.oregonstate.edu/concern/honors_college_theses/7d278v80q

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  • Heavy chronic alcohol consumption has been linked to a myriad of detrimental skeletal effects. Many studies have been conducted to examine the effects of alcohol abuse upon cancellous bone. However, little is known about its effect upon cortical bone. The skeleton is comprised of approximately 80% cortical bone and thus alcohol induced alterations may play a role in increased fracture risk. A 6 month voluntary self-administration of ethanol study was conducted on cynomolgus monkeys to determine the effects of heavy alcohol consumption on bone mass, microarchitecture, and intracortical bone remodeling. Animals consumed an average of 1.83g per kg body weight of ethanol (4%v/v) per day, approximately equivalent to 10 standard drinks a day for a 75kg person. Examinations of the 3rd lumbar vertebra, distal femur, and distal tibia were conducted using DXA, µCT, and histological techniques. There were no differences in the bone mass or bone microarchitecture between alcohol consuming animals and the control group. Alcohol consuming animals showed a trend towards lower intracortical bone resorption and formation. The data suggests that 6 months of heavy alcohol consumption does not affect bone mass or microarchitecture but may depress intracortical bone remodeling. Key Words: Alcohol abuse, Cynomolgus model, Cortical bone remodeling, Haversian remodeling, Histomorphometry, Microcomputed tomography
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