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  • Metabolic disorders affect much of the population, and it is widely believed that they have a genetic basis as well as being influenced by dietary factors. Recent studies have revealed an important role for the neil1 gene in the prevention of metabolic diseases. NEIL1 is a DNA Glycosylase that catalyzes the repair of DNA and mtDNA. We aimed to understand how a deletion in the neil1 gene in a mouse model would affect susceptibility to high fat and high carbohydrate diets. We also sought to establish a role for pro- and antioxidants in modulating disease risk. To accomplish this, Wild Type (WT) and neil1 Knockout (KO) mice were placed on either high fat or high carbohydrate diets. In a cohort of animals, the high fat diet was supplemented by the pro-oxidant KBrO3, or the antioxidant N acetyl cysteine. Under the oxidative stress of a high fat diet, the KO mice gained more weight than the WT mice. A similar difference was observed for the high carbohydrate treatment. The pro-oxidant KBrO3 seemed to mitigate the weight gain phenotype that was characteristic of a high fat diet, whereas the antioxidant NAC had no effect in both kinds of mice. At this point, the conclusion can be drawn that neil1-KO animals are more prone to the weight gain (and attendant effects of metabolic syndrome) induced by high fat and high carbohydrate diets.
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  • description.provenance : Made available in DSpace on 2012-06-13T01:32:50Z (GMT). No. of bitstreams: 3Presentation Part 3.ppt: 493568 bytes, checksum: a5f696fd7d95e012441ba48b59070fda (MD5)Presentation Part 2.ppt: 722944 bytes, checksum: 4c617e62a0e49f7258056edc9bd15cf6 (MD5)Presentation Part 1.ppt: 90624 bytes, checksum: 47d7ac3474da4b028c05b105137d77cb (MD5)
  • description.provenance : Submitted by Maanas Tripathi (tripathm@onid.orst.edu) on 2012-06-06T18:06:32ZNo. of bitstreams: 3Presentation Part 3.ppt: 493568 bytes, checksum: a5f696fd7d95e012441ba48b59070fda (MD5)Presentation Part 2.ppt: 722944 bytes, checksum: 4c617e62a0e49f7258056edc9bd15cf6 (MD5)Presentation Part 1.ppt: 90624 bytes, checksum: 47d7ac3474da4b028c05b105137d77cb (MD5)
  • description.provenance : Approved for entry into archive by Sue Kunda(sue.kunda@oregonstate.edu) on 2012-06-13T01:32:50Z (GMT) No. of bitstreams: 3Presentation Part 3.ppt: 493568 bytes, checksum: a5f696fd7d95e012441ba48b59070fda (MD5)Presentation Part 2.ppt: 722944 bytes, checksum: 4c617e62a0e49f7258056edc9bd15cf6 (MD5)Presentation Part 1.ppt: 90624 bytes, checksum: 47d7ac3474da4b028c05b105137d77cb (MD5)

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