Cancer is class of diseases that has great diversity and unfortunately is one of the leading causes of death in the United States. Chemotherapy remains an important cancer treatment modality, and superior chemotherapeutic drugs are constantly being sought. Gemcitabine is an anti-tumor chemotherapeutic drug and it is the first line of defense in treating pancreatic cancer, as well as, used in combination therapy for non-small cell lung, ovarian, and metastatic breast cancers. Patients with cancer, specifically pancreatic carcinoma, have a high mortality rate which highlights the poor anti-tumor activity of gemcitabine. The anti-tumor activity of gemcitabine shows needed improvement due to its short half-life and low specificity in patients. The objective of this study is to utilize lecithin-based nanoparticles (NP) as a delivery system for a lipophilic gemcitabine prodrug. From this current study, a maximum drug concentration of 5 mg/ml was achieved into nanoparticles, thereby improving anticancer activity of gemcitabine.
Keywords: Gemcitabine, nanoparticles, chemotherapy