Activation and Nuclear Translocation of the Transcription Factor Nrf2 by the MAP Kinase Family Public

http://ir.library.oregonstate.edu/concern/honors_college_theses/bz60cz50s

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  • Eukaryotic cells have developed elaborate biochemical processes to counteract oxidative stress, electrophiles, or carcinogens due to environmental insults. One of these important cellular defense mechanisms is mediated by the transcription factor Nrf2 that have been shown to have decrease activity with age. While the process of which Nrf2 is involved with has been extensively studied, its exact mechanism for activation is still unclear. Using HepG2 cell cultures, nuclear extraction techniques, SDS-PAGE, Western Blotting, Chemical Inhibitors, and EMSA, we showed that the MAP Kinase family is involved in the activation of Nrf2. Future direction will be towards determining exactly which proteins in the MAP Kinase family is involved in this activation and whether or not it has decrease activity with age.
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